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doi: 10.1002/mds.26734

GLP-1 medications can produce substantial caloric restriction through appetite suppression and early satiety, leading to weight loss that may exceed 15-20% of body weight over several months with higher doses of semaglutide 2.4 mg or tirzepatide

While access remains uneven across commercial plans and Medicare coverage for obesity medicines is still limited, CVS decision signals continued normalization of GLP-1 therapies within mainstream pharmacy benefit design and intensifies competition between Lilly and Novo Nordisk for long-term market leadership in obesity careTop of FormBottom of Form Sources CVS brings back coverage for Lilly's obesity drug Zepbound Reuters May 28, 2026 Eli Lilly downplays CVS move to drop Zepbound coverage, shares plunge Reuters May 1, 2025

A Cleveland Clinic team led by cardiologist Amgad Mentias, MD, recently published a large database analysis showing that bariatric surgery in Medicare enrollees with obesity was associated with lower risk of mortality, new-onset heart failure and myocardial infarction ( J Am Coll Cardiol