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GLP-1 RAs induced an early dip in eGFR, suggesting decreased intraglomerular pressure and decreased glomerular hyperfiltration, followed by slower eGFR loss in the overall population of GFR subgroups compared with placebo [13, 20], a feature shared with all currently known nephroprotective drugs ranging from reninangiotensin blockers to mineralocorticoid receptor antagonists to SGLT2is to tolvaptan [67]

According to the World Health Organization (WHO), over 60 million people in Europe live with diabetes, while noncommunicable diseases account for nearly 90% of deaths in the region, driving increased demand for effective treatments such as GLP-1 receptor agonists

this effect disappears when you stop taking the drug

These effects collectively improve blood sugar control in patients with type 2 diabetes

Almandoz noted that some of his patients who struggled with shopping or gambling addictions described improvements in these impulse-control conditions, too