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Some studies have suggested that the proliferation and apoptosis of granulosa cells (GCs) are the root causes of follicular development and atresia, with forkhead box protein O1 (FoxO1) playing an important role in promoting PCOS follicular atresia and GCs apoptosis (162, 163)

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16 HOW SUPPLIED/STORAGE AND HANDLING How Supplied Single-patient-use pens (with multiple weekly doses): Injection: clear, colorless solution of 0.68 mg/mL, 1.34 mg/mL or 2.68 mg/mL of semaglutide available in the following packaging configurations: Each OZEMPIC multi-dose pen is for use by a single patient