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Additionally, it has been suggested that GIPR agonists and antagonists might target different CNS receptor populations, with evidence showing that acylated peptide GIPR agonists act on GABAergic neurons to further reduce food intake and body weight when combined with GLP-1R agonists in mice 39,40

You guys are all clinicians, but I just dont want anybody to go like, oh yes, and I went and did this and didnt work for my patients

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Orforglipron, by contrast, is a small molecule drug that can be absorbed through the gut wall, making it viable as a daily pill

However, we may need to hold off before we pop the champagne