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In addition to directly impacting gut motility on a pharmacologic basis, GLP-1s are used to modify behavioral food and fluid patterns

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Across multiple trials involving thousands of participants, the 2.4mg weekly dose consistently produced average weight losses between 14% and 17% of starting body weight

Subject of Research : Animals Article Title : Semaglutide suppresses cocaine taking, seeking, and cocaine-evoked dopamine levels in the nucleus accumbens News Publication Date : 10-Jul-2025 Web References : 10.1016/j.euroneuro.2025.07.001 Image Credits : Photo: Johan Wingborg, Elin Lindstrm Keywords : semaglutide, cocaine addiction, GLP-1 receptor agonists, dopamine, nucleus accumbens, relapse, pharmacotherapy, substance use disorder, drug repurposing, experimental study Tags: addiction medicine breakthroughsanimal models of addiction behaviorcocaine consumption reduction in ratsdopamine signaling and addictionglucagon-like peptide-1 receptor agonistsimplications for treating substance use disordersmetabolic effects of semaglutide in addictionneuropharmacology of semaglutidepreclinical studies on drug addictionsemaglutide and cocaine addictiontherapeutic agents for cocaine dependencyUniversity of Gothenburg research findings

Thyroid Tumors GLP-1s, such as semaglutide, include a warning for the risk of thyroid C-cell tumors in the US