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14 Obesity can also impact the pharmacokinetics of therapies through changes to volume of distribution and drug clearance, 15 and may negatively alter the efficacy of therapies used to treat IBD

Class effects, which are directly related to the mechanism of action, are common to all DPP4i

60 However, in humans, early studies demonstrated that GLP-2 administration for five weeks increased spinal BMD in people with short bowel syndrome, 62 but had limited overall bone benefits

Established cardiovascular disease

Direct-to-consumer advertising has elevated patient demand, while robust clinical and prescribing ecosystems make the U.S
