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As described previously, ambient temperature and humidity range were set at 6484 F and 3070%, respectively and lighting in the animal-holding rooms was maintained on a 12-h lightdark cycle 34

In rats, the LWP-induced GLP-1 secretion further improves glucose tolerance and enhances insulin secretion, an effect that is blocked by pre-administration of the GLP-1R antagonist exendin (939) [306]

3.4 Complications and side effects of GLP-1 RAs Common side effects associated with GLP-1 receptor agonists (GLP-1 RAs) include gastrointestinal symptoms such as nausea (2560%), diarrhea, and vomiting (515%) (46)