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A branded drug can lose between 80% and 90% of its revenue within the first year of facing generic competition, with the originators sales plummeting as much as 80-90% within the first year of generic entry

Some describe it as improvement

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Most people find that their body eventually finds a new normal. Eat smaller portions to avoid overstimulating the gut-brain axis

In particular, our analysis reveals an odds ratio of 3.11 (95% CI [1.33, 7.24]) when comparing the pancreatitis risk of patients reporting adverse effects at a cumulative dose of larger than 5300 mg and those at a cumulative dose of less than 5300 mg