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25 To a lesser extent, this same phenomenon has been reported in studies of aggressively treated type 2 diabetic patients and in obese diabetic patients treated with bariatric surgery that resulted in a lowering of hemoglobin A1c along with weight loss

Many of these incidents involved dosing errors that resulted in hospital visits

Consequently, a 30-pound weight loss could reduce knee loading by 90-120 pounds with each step, representing substantial mechanical relief

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These medications have proven highly effective at treating type 2 diabetes and obesity, and recently gained approval to help reduce cardiovascular events