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No causal relationship has been established in humans to date, and population-level data from large GLP-1 user cohorts have not shown a clear increase in MTC incidence.[5] That said, there are defined contraindications: GLP-1 therapy is not appropriate for patients with a personal or family history of MTC or Multiple Endocrine Neoplasia type 2 (MEN2 syndrome)

The disease's growing incidence, prevalence, and progressive nature have encouraged the development of new drugs to provide additional treatment options for dietic patients

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The risk of worsening substance use disorder dropped by 47%

doi:10.1016/S2213-8587(15)00482-9 3