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Description
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Exendin-4, a stable synthetic form of GLP-1, is commonly used clinically for diabetes treatment because GLP-1 has a short half-life (Drucker and Nauck, 2006
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Efficacy signal: Trial data shows tirzepatide achieves 20.9% average weight loss (SURMOUNT-1) versus semaglutide's 14.9% (STEP 1), but individual outcomes vary and no obesity-specific switching trial exists yet
