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these were SUSTAIN 1, 2, 3, 6, and SUSTAIN-Japan [13,14,15, 19, 20]

Terminal quantitative endpoints included plasma/liver biochemistry, liver histomorphometry and RNA sequencing

Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs

[DOI] [PubMed] [Google Scholar] 42.Lundgren J.R., Janus C., Jensen S.B., et al

The phone call was answered quickly and the representative was direct and helpful