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An EMA official told the BBC that testing is being carried out as part of a procedure brought up by the Icelandic Medicines Agency, following these three cases

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Include a detailed letter of medical necessity, peer-reviewed literature supporting the prescribed medication, the patient's complete clinical history, and documentation of failed alternative treatments

Cardiovascular Diabetology, 8(1), 12

We addressed incoherence (inconsistency) both locally by comparing directly with indirect evidence using the Separating Indirect from Direct Evidence (SIDE) method [19] and globally using the design-by-treatment interaction model [20]