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It is precisely this fragmentation of authority that is now being absorbed into technological systems

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Future studies with larger cohorts of both sexes and with broader molecular analyses will be needed to fully validate whether certain functions of GADD45A may be compensated in females and to further elucidate the sex-dependent functions of GADD45A

Critical Appraisal (EP Edge Take) The absolute event rates are not enormous, but the signal is durable and clinically meaningful because it spans: (a) atrial arrhythmias, (b) conduction disease requiring devices, and (c) hard outcomes like cardiac arrest a broad electrical phenotype rather than a single arrhythmia endpoint