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Description
The mechanism involves activation of PKC, ERK, and CaM kinase II pathways, as well as GPR40/120 receptors on L-cells (Takikawa et al., 2019)

Magnani JW, Norby FL, Agarwal SK, et al

This is often what we do to help out patients with chronic pancreatitis who develop EPI and diabetes

This regulation is primarily mediated by the peptide hormones GLP-1, glucagon, and GIP, which activate these receptors, leading to a signaling cascade and the formation of an active receptor-G protein complex 7

The authors conclude that this type of fasting is feasible and may have clinical benefits (130)
