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Incretins, such as GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), are secreted by entero-endocrine cells of the gastrointestinal tract to stimulate glucose-dependent insulin secretion and beta-cell proliferation
Understanding the implications of upstream GLP-1 signaling may provide context for metabolic disease states, where abnormalities in the TGR5 signaling pathway attenuate robust GLP-1 activity
The peptide is made with a specific amino acid sequence to ensure stability and consistency during research
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