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Drug discrimination procedures are well-established in both human and preclinical studies for assessing subjective/interoceptive effects (Grant and Bennett 2003

Cell Metab 13: 308-319, 2011

[DOI] [PubMed] [Google Scholar] Meuleman T

Karagiannis (Clinical Research and Evidence-Based Medicine Unit, Aristotle University of Thessaloniki, Greece) assisted in the credibility assessment and interpretation of meta-analyses evaluating the effects of glucose-lowering medications across subgroup populations and contributed in applying GRADE guidance in the formulation of respective practice recommendations

These more motivated patients may exhibit other positive behaviors such as maintaining a healthy diet and engaging in regularexercise, which could provide further protection against fractures