tirzepatide pdufa date FDA Approves Tirzepatide, A Potential Blockbuster Drug for Type 2 Diabetes Tirzepatide Dosing Chart 2026: 2.5-15

What happens when tirzepatide clears your system, why weight regain is common, and what a proper off-ramp plan looks like

As of February 23, 2026, the manufacturer has a promotion for the Zepbound Self Pay Journey Program, which lowers rates to $449 for each 1-month supply of the 7.5 mg, 10 mg, 12.5 mg, and 15 mg Zepbound single-dose vial or Zepbound KwikPen for single-patient-use

Steady-state plasma concentrations are reached after roughly four weeks of once-weekly dosing, per the FDA label, so four weeks is not arbitrary

SURPASS-2: The Only Head-to-Head Trial The SURPASS-2 trial (NEJM, 2021) is the most important study in this comparison because it directly tested tirzepatide against semaglutide in 1,879 patients with type 2 diabetes over 40 weeks

Yes, and many diabetes trials added tirzepatide on top of metformin