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Losing excess weight may reduce inflammation, improve energy, reduce joint strain, improve blood pressure, and lower the risk of diabetes and heart disease

The SURMOUNT-1 and SURPASS-5 trials summarize weight loss and glycemic benefits, again, both associated with reduced risk and progression of DN, but this study does not present direct clinical trial evidence of tirzepatide improving established neuropathy [41, 42]

These sweeteners may come from plant sources, undergo less processing, or have a lower glycemic index (GI), making them more suitable for people with dietary restrictions, including diabetics, GLP-1 users, and those following ketogenic or paleo diets

doi: 10.1038/nature22394 44 FinanBMaTOttawayNMllerTDHabeggerKMHeppnerKMet al

Furthermore, a recent meta-analysis published in Italy in July 2023 did not show an association of pancreatic cancer with GLP-1 RA use [88]