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It differs from the gastrointestinal discomfort that tirzepatide sometimes causes, which tends to be more diffuse and centered around the stomach or intestines rather than the lower pelvis

People who remain sedentary lose substantial muscle mass alongside fat, often reducing metabolic rate by 200-300 calories daily by month 12

doi: 10.2217/fca-2022-0093

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Pregnancy considerations: Tirzepatide is not recommended during pregnancy, and women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during initiation and dose escalation