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For a long time, the manifestation of depressive symptoms has been also associated with the deficits in neurotrophic factor action in the brain [51], especially highlighting the role of diminished brain-derived neurotrophic factor (BDNF) signaling as important for the pathogenesis of this mental disorder [52]

Discussion Current research suggests a close relationship between glucose metabolism disorders and energy conversion disorders and PD pathogenesis

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Although proven effective, GLP-1 RAs have been associated with numerous GI adverse events