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For the treatment of T2D, the FDA gave their approval in 2017

In the case of semaglutide, it's posited that the medication's effectiveness in reducing appetite and promoting weight loss could inadvertently lead to amenorrhea
That's why more people are asking: Can certain foods naturally support GLP-1 release

Both the potentiation of GLP-1 effects on body weight by estrogen, as well as the more robust food motivated behavior suppression achieved by GLP-1R activation in females may translate to higher efficacy of GLP-1 analogs in patients

By feeding mice HFD, obesity was modeled
