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Tamborlane WV, Barrientos-Perez M, Fainberg U, et al

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"I think that's why we're seeing certain companies who are willing to stay and test the waters." According to FDA's guidance documents for industry , Congress didn't bar just compounding of exact copies, but included the word "essentially" in the law "to ensure that compounders do not evade the limits in this section by making relatively small changes to a compounded drug product and then offering the drug to the general public without regard to whether a prescribing practitioner has determined that the change produces for the patient a significant difference." Minor changes in strength aren't enough, the document says

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In rodent models, activation of the GLP-1 neurons also results in activation of stress responses, including anxiety-like behavior (Maniscalco and Rinaman, 2018)