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There were no animal studies or even basic physiology suggesting they would be helpful for the cardiovascular system. In 2008, the FDA ordered a series of cardiovascular outcomes trials after two studies suggested lowering blood sugar could be dangerous for the heart in patients with type 2 diabetes, Nauck said
Addressing low-grade inflammation associated with obesity, reducing cardiovascular burden, and achieving overall health improvement remain significant unmet needs in PsD

Ferrannini E, Mark M, Mayoux E

GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review

Similar benefits were observed for kidney disease progression alone and for a composite of ESKD and cardiovascular death
