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They reduce caspase-3 mRNA activity and enhance the expression of anti-apoptotic genes, including Bcl-2 and Bcl-xl [45, 46]

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But allowing unauthorized manufacturers to mass market GLP-1 knockoffs outside FDA safeguards creates significant patient safety risks and undermines trust in the healthcare system. GLP-1 medicines such as semaglutidemarketed as Ozempic and Wegovyand tirzepatidesold as Mounjaro and Zepboundhave become among the most widely used diabetes and weight loss treatments

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FDA clarifies policies as national GLP-1 supply stabilizes

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