can semaglutide make depression worse The interface of and diabetes: treatment considerations GLP-1 Agonists Can Affect Mood:
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Even after losing excess weight with medication or diets, people may still struggle with daily activities such as walking briskly or climbing stairs

Serious gastrointestinal adverse events also occurred at similar rates in those with AF (3.6% of semaglutide-treated participants vs 1.9% of participants receiving placebo) and without AF (2.2% of semaglutide-treated participants vs 2.3% of participants receiving placebo)
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However, its important to discuss this with your healthcare provider to ensure that the combination is safe and effective for you