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Initial doses of 0.25 mg (7.5 units) increase by 0.25 mg weekly until reaching a therapeutic dose between 2.42.5 mg (7275 units) weekly, though individual protocols vary by provider and clinical context

The response is mediated by a shortened cycle length and steeper diastolic depolarization potential of pacemaker action potentials and a shift of the site of earliest activation within the sinus node

That's what patients who take Novo Nordisk's Rybelsus, a pill form of semaglutide, have to do, according to Siegel

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Treatment duration varies depending on weight goals and provider direction, but consistency is key