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Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease

[20] [19] If you're struggling to achieve your treatment goals or experiencing side effects from your current medications, discuss alternative options with your GP or diabetes specialist nurse

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The supplement industry rushed to capitalize on GLP-1 popularity, flooding the market with products making bold claims

We also found that UCP2 silencing did not alter PPAR expression levels (Fig