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Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells

Key exclusion criteria included diagnosis of diabetes, prior or planned surgical treatment for obesity, or if within 90 days before screening they had received treatment with a medication for weight reduction or a GLP-1 receptor agonist, or a change in body weight of more than 5 kg

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A multicenter, phase 2 study on subject with obesity was then performed: 957 people were randomized to the treatment with doses of semaglutide between 0.05 mg, 0.1 mg, 0.2 mg, 0.3 mg and 0.4 mg/day or placebo