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Mar 3, 2026 Two drugs

In three separate SUSTAIN trials, semaglutide 1 mg conferred a greater weight loss among adults with type 2 diabetes than exenatide 2 mg (Bydureon, AstraZeneca), dulaglutide 1.5 mg (Trulicity, Eli Lilly) and liraglutide 1.8 mg (Saxenda, Novo Nordisk)
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Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: The SURPASS-5 randomized clinical trial

After five half-lives (25 days), approximately 3.1% of the last dose remains in circulation

Prior medication history matters
