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To make it work, they have to understand that its dosed slowly and low to mitigate the side effects, and that you really do have to be on a high-protein, low-calorie diet, you have to eat healthy, and you have to exercise, Apovian said

Archives of physiology and biochemistry, 130(6), 678685

The best advice is to eat three to four protein-forward, balanced meals daily - spaced three to four hours apart

In clinical trials, participants taking semaglutide lost approximately 15% of their body weight on average, compared to about 2.4% in the placebo group