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The medication affects multiple bodily systems, which explains why some patients experience headaches during treatment initiation or dose adjustments

Early assessment ensures appropriate diagnosis and management, particularly to exclude serious underlying conditions that may require specific treatment

The combination of strong clinical data, favorable tolerability, and advancing regulatory status positions it well for expanded global availability

High tubular flow enhances potassium secretion by activating Maxi-K channels and promoting ROMK function via luminal potassium dilution and increased sodium uptake through epithelial sodium channels (ENaC) [35]

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