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[10] Pichette, J., Fynn-Sackey, N., and Gagnon, J

Although current guidelines suggest a conservative strategy for addressing bowel dysfunction, which includes techniques such as digital rectal stimulation (DRS) and abdominal massage, the availability of interventions remains limited in healthcare facilities

The specificity of these effects is further supported by the observation that GLP-1R agonists reduce reinstatement of cocaine-seeking behavior without altering inactive lever responses or general locomotor activity

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For example, the standard therapeutic dose of semaglutide for weight loss reaches up to 2.4 mg weekly