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Phase 2 trial data documented mild dose-dependent heart rate elevation and a thermogenesis-related signal that may translate to mild sweating in higher-dose subjects

A recent review listed on PubMed looks at how these metabolic and immune systems interact in the case of dual-agonist therapies

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THE SIMPLE PLAN What to do first What to add What works best together FOUNDATION Protected Lean Muscle (LOAD) If you do one thing while on a GLP-1, it should be protecting lean muscle

A 2024 retrospective analysis suggested no significant excess of kidney stones with GLP-1 use compared to other anti-obesity therapy
