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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked
These actions have been clinically exploited by the development of amylin and GLP-1 hormone analogs now used for treatment of diabetes and obesity
Dit verzadigingshormoon speelt een essentile rol speelt bij het reguleren van de bloedsuikerspiegel en het verhogen van verzadiging
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