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In summary, GLP-1 receptor agonists exert anti-fibrotic effects in MASLD through the inhibition of hepatic stellate cell activation, the modulation of profibrotic signaling pathways, and the promotion of hepatocyte regeneration

Glucagon-like peptide-1 receptor agonist prevented the progression of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

Ongoing and planned trials (Supplementary Table 3

When GIP receptor activation combines with GLP-1 stimulation, as it does with tirzepatide dosing protocols , the result is enhanced insulin sensitivity, improved lipid metabolism, and a reduction in pathological fat deposition

Annals of internal medicine , 177 (8), 10161027