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Exploring the rates of Gastrointestinal adverse effects among five GLP-1 receptor agonists: A systematic review and Meta-Analysis of randomized controlled trials

Stick with the 4-week timeline at 2mg, then escalate to 4mg as planned

Also, our investigation revealed that the AA group displayed increased levels of IL-6, which was corroborated by a previous study by Ansari et al

JAMA points out that "these adverse events, although rare, must be considered by patients who are thinking about using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes" [20]

While some studies have demonstrated changes in insulin signaling pathways and neurotrophic markers, others have failed to detect meaningful alterations in dopaminergic imaging [32, 34, 54, 55, 61]