glp 1 gip gcg Biology of Incretins: GLP-1 and The Clinical Application of GLP-1RAs

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The main roles of GLP-1 are stimulation of glucose-dependent insulin secretion, inhibition of postprandial glucagon release, delay of gastric emptying, and induction of pancreatic -cell proliferation [5]

Key Toxicities to Watch as a clinical pharmacist: Renal: nephrotoxicity, rising creatinine Neuro: tremors,confusion, seizures Metabolic: hypertension, QT prolongation, hyperglycemia Electrolytes: K, Mg Heres how we intervene before toxicity takes over: Slash Tacrolimus doses by ~70% when starting Posaconazole TDM every 23 days (dont wait for trouble) Monitor renal function, BP, electrolytes, glucose closely Anticipate the reverse interaction when Posaconazole is stopped tacrolimus levels crash without timely adjustment Key Insight: Pharmacists arent just dose adjusters. We are the safety net that spots silent drugdrug collisions before they harm patients

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Exercise addresses multiple causes of weight gain simultaneously