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You can read the abstract of this article at In the SURPASS-4 trial, the dual GIP and GLP-1 receptor agonist tirzepatide demonstrated superior reductions in HbA1c concentrations, bodyweight, and blood pressure compared to titrated daily insulin glargine in individuals with type 2 diabetes and cardiovascular risk

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I also had a family history of heart disease, borderline glucose, and sluggish metabolism

J Clin Lipidol

Both systemically administered in mice and centrally administered exenatide into the VTA in rats decreased cocaine selfadministration (Schmidt et al., 2016