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In some trials, improvements in mood appeared independently of changes in HbA1c, pointing to potential neuropsychiatric effects that go beyond glycemic normalization [8,65,66]

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41 The membrane depolarisation causes voltage-gated calcium channels in the cell membrane to open leading to calcium ion influx into the cell, which then results in the exocytosis of insulin vesicles stored in the cytoplasm

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Whilst sleep disturbances may occur indirectly through gastrointestinal symptoms, metabolic changes, or lifestyle adjustments during treatment, no direct causal link between tirzepatide and primary insomnia has been established