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Developmental delay/intellectual disability, learning difficulties, behavioral problems, and autistic features are common [5,6]
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Kidney disease secondary to T2DM and obesity demonstrates similar pathogenesis, with long-term decreases in glomerular filtration rate (GFR), nephrosclerosis, and progression to end-stage renal disease, where GLP-1 receptor agonist (GLP-1RA) treatment slows CKD progression, measured by an attenuated decline in GFR in patients with either T2DM or obesity and CKD [12,13]
Direct TRPV1 Channel Modulation: GLP-1 and analogs directly interact with TRPV1 channels on peripheral nociceptors
