semaglutide vs tirzepatide comparison efficacy side effects Cardiovascular outcomes of and for patients with type 2 diabetes in clinical practice tirzepatide vs semaglutide comparison efficacy

The slowed gastric emptying can influence how patients tolerate different foods, particularly those that are rich, fatty, or heavily spiced

The most frequent injuries involve long-term digestive problems, inflammation of the pancreas, gallbladder disease, kidney injury, and growing concerns about thyroid tumors

One other downside that I think you didn't point to specifically, but you meant in saying there's some unknown downside to this, there are some early studies that are showing that you lose more lean muscle mass when you're on a GLP-1 than if you were just doing diet and exercise

Nat Rev Endocrinol 8(12):728742

dehydration can exacerbate feelings of fatigue and muscle cramps