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This program does not require strict dieting or intense exercise regimens, yet it consistently helps with delivering substantial results

Perhaps most convincingly, rat studies in which plasma glucose and lactate levels were measured in the inferior vena cava, hepatic vein, hepatic portal vein and the aorta demonstrated that the plasma lactate concentration peaks in the hepatic portal vein, with a corresponding drop in the plasma glucose concentration

Research Evidence Comparison# Retatrutide Research# Phase 1 : First-in-human study established safety and pharmacokinetics Phase 2 (n=338) : Published in NEJM (2023), demonstrated dose-dependent weight loss up to 24.2% at 48 weeks with 12 mg dose

Furthermore, GLP-1 exerts effects on the gastrointestinal tract by slowing the gastric emptying rate and small intestinal peristalsis, and by reducing pancreatic exocrine secretion of bile acids, digestive enzymes, and bicarbonate