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Severe symptoms need in-person evaluation, and all final treatment decisions depend on the clinicians assessment rather than location-based search intent alone

Direct head-to-head comparison of tirzepatide vs semaglutide was conducted in the SURPASS-2 trial, which showed tirzepatide 15mg weekly produced significantly greater HbA1c reduction (-2.46% vs -1.86%) and weight loss (-12.4 kg vs -6.2 kg) compared to semaglutide 1mg weekly in type 2 diabetes

Incretin-based dual agonist therapy may offer an alternative to stringent dietary restriction and challenge the success of bariatric surgery in the diabesity community INTRODUCTION The incretin effect, an augmented prandial insulin response, is mediated mostly by the hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), which are released from the intestines after meals

Bariatric surgery success probably results from a range of networking factors rather than a single unifying mechanism

Funding: This study was supported by the Department of Veterans Affairs via grant BX004299 (to RS Peebles Jr)