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By simultaneously targeting the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, Tirzepatide offers a novel approach to metabolic health

Using the same spot repeatedly can cause lipodystrophy, localized changes in the fat layer that create lumps or indentations and can affect absorption consistency

I waited one week after my last tirzepatide shot and started retatrutide at 2 mg, titrating up slowly

Patients on these drugs do experience drops in blood pressure, and if blood pressure gets low enough, they may be able to come off some of their other blood pressure medications, he says

It is not dramatic