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Materials and Methods Mean percent change in weight from baseline, weight reduction 5% and mean change in glycated haemoglobin (HbA1c [%]) were compared between tirzepatide 10/15 mg (week 72, SURMOUNT2) and semaglutide 2.4 mg (week 68, STEP 2) applying the Bucher method to the efficacy estimand

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is a consultant for AstraZeneca, Alexion, Bayer, Boehringer Ingelheim, CSL-Behring, DIMERIX, Eli Lilly, Gilead, Janssen, Novartis, Novo Nordisk, Roche, Travere Pharmaceuticals and VIFOR Pharma