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Baseline B12 assessment should be considered before starting GLP-1/GIP therapy, particularly in patients taking metformin, following plant-based diets, or with malabsorption conditions

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The ability of GLP-1 receptor agonists to reduce food cravings and quiet food noise appears to stem from their effects on brain reward circuitry

For A 25-35 -treated mice, liraglutide dose-dependently prevented against A 25-35 -induced impairment of spatial learning and memory, prevented depression of hippocampal L-LTP, and upregulated intracellular cAMP level (177)