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Reshaping the inflammatory environment in rheumatoid arthritis joints by targeting delivery of berberine with platelet-derived extracellular vesicles

Simon J, Wienand D, Park AL, Wippel C, Mayer S, Heilig D, et al

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They are pharmacologically different molecules, and only the DAC form has published human data

Additionally, some patients unconsciously increase portion sizes or snacking frequency as medication side effects subside, offsetting the calorie deficit created by reduced hunger