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However, it should be noted that combined with insulin may lead to hypoglycemia (94)

Preclinical data indicated that tirzepatide exhibited an affinity for GIPR equivalent to GIP binding, while its affinity for GLP-1R was approximately five times weaker compared to GLP-1 (63)

Importantly, this increased GCG receptor activity did not adversely impact glycemic control

Acute pancreatitis associated with liraglutide

4.4 Potential effects of tirzepatide on upper airway function In addition to metabolic and inflammatory modulation, emerging evidence suggests that incretin-based therapies may influence upper airway neuromuscular control
