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Findings In this economic evaluation of 30 million cumulative Medicare beneficiaries identified as eligible for new GLP-1RAs for obesity treatment over the next 10 years, Medicares total projected costs for drug coverage of the GLP-1RAs were $65.9 billion

Participation in a clinical trial is the only legitimate and safe route to accessing retatrutide at this stage

These trials test retatrutide for obesity, type 2 diabetes, cardiovascular disease, knee osteoarthritis, and liver disease (Giblin et al., Diabetes, Obesity and Metabolism 2026)

In some cities, needle anxiety remains a clear barrier to treatment adoption, particularly in areas where fear or phobia rates are highest

Semaglutide is meant to be taken regularly as a lifelong drug